Origin of Th17 Cells in Type 2 Diabetes-Potentiated Periodontal Disease

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

New strategies are critically needed to counter uncontrolled periodontal infection and inflammation in obesity-associated type 2 diabetes (T2D). However, mechanisms that explain the relationship between periodontitis (PD) and T2D remain poorly understood. Several lines of evidence indicate that destructive immune responses potentiate periodontitis (PD) in T2D. B cells are abundant in periodontal lesions, and our data show that B cells are required for PD in obese/insulin resistant but not lean/normoglycemic mice. In mice and in people, T2D-primed B cells supported Th17 cytokine profiles, but B cells had a modest effect on T-cell function in samples from normoglycemic individuals. Given the recently appreciated importance of Th17 cells in PD outside a T2D milieu, our data raise the possibility that B cells indirectly promote T2D-potentiated PD through support of Th17 cells, which in turn directly promote PD. Data herein thereby suggest unexpected mechanisms that explain the clinical observation that T2D potentiates PD.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages45-54
Number of pages10
DOIs
StatePublished - 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1197
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© 2019, Springer Nature Switzerland AG.

Keywords

  • B cells
  • Inflammation
  • Metabolic disease
  • Obesity
  • Periodontitis
  • Th17 cells

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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