TY - JOUR
T1 - Orthostatic hypotension and the incidence of coronary heart disease
T2 - The atherosclerosis risk in communities study
AU - Rose, Kathryn M.
AU - Tyroler, Herman A.
AU - Nardo, Christopher J.
AU - Arnett, Donna K.
AU - Light, Kathleen C.
AU - Rosamond, Wayne
AU - Sharrett, A. Richey
AU - Szklo, Moyses
PY - 2000
Y1 - 2000
N2 - We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women participating in the Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a SBP decrease ≥ 20 mm Hg or a DBP decrease ≥ 10 mm Hg after changing from supine to standing. CHD events included definite or probable myocardial infarctions (MI), silent MI, and fatal CHD. Five percent of participants had OH. Prevalence increased with advancing age and was more common among those with cardiovascular disease (CVD)-related comorbidities and risk factors. Those with OH had an increased risk of CHD (hazard ratio [HR] = 3.49, 95% confidence interval [CI] = 2.58, 4.73). This association was attenuated after controlling for age, ethnicity, gender, comorbid conditions, and CVD risk factors (HR = 1.85, 95% CI = 1.31, 2.63).
AB - We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women participating in the Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a SBP decrease ≥ 20 mm Hg or a DBP decrease ≥ 10 mm Hg after changing from supine to standing. CHD events included definite or probable myocardial infarctions (MI), silent MI, and fatal CHD. Five percent of participants had OH. Prevalence increased with advancing age and was more common among those with cardiovascular disease (CVD)-related comorbidities and risk factors. Those with OH had an increased risk of CHD (hazard ratio [HR] = 3.49, 95% confidence interval [CI] = 2.58, 4.73). This association was attenuated after controlling for age, ethnicity, gender, comorbid conditions, and CVD risk factors (HR = 1.85, 95% CI = 1.31, 2.63).
KW - CHD
KW - Middle-age
KW - Orthostatic hypotension
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U2 - 10.1016/s0895-7061(99)00257-5
DO - 10.1016/s0895-7061(99)00257-5
M3 - Article
C2 - 10912737
AN - SCOPUS:0033927689
SN - 0895-7061
VL - 13
SP - 571
EP - 578
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 6 II SUPPL.
ER -
