Background Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM). Methods A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used. Results A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results. Conclusions BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.
|Number of pages||8|
|Journal||American Journal of Surgery|
|State||Published - Dec 2013|
Bibliographical noteFunding Information:
This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech .
Copyright 2014 Elsevier B.V., All rights reserved.
- Lymphovascular invasion
- Melanoma histology
- Melanoma prognosis
- Nonsentinel lymph node melanoma
- Sentinel lymph node biopsy melanoma
- Superficial spreading melanoma
ASJC Scopus subject areas