Abstract
Background Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM). Methods A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used. Results A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results. Conclusions BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.
Original language | English |
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Pages (from-to) | 861-868 |
Number of pages | 8 |
Journal | American Journal of Surgery |
Volume | 206 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2013 |
Bibliographical note
Funding Information:This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech .
Funding
This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech .
Funders | Funder number |
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Schering Oncology Biotech |
Keywords
- Lymphovascular invasion
- Melanoma histology
- Melanoma prognosis
- Nonsentinel lymph node melanoma
- Sentinel lymph node biopsy melanoma
- Superficial spreading melanoma
ASJC Scopus subject areas
- Surgery