Outcomes and prognostic factors in superficial spreading melanoma

Michael E. Egger; Lindsay O. Stepp; Glenda G. Callender; Amy R. Quillo; Robert C.G. Martin; Charles R. Scoggins; Arnold J. Stromberg; Kelly M. McMasters

doi:10.1016/j.amjsurg.2013.09.003

Outcomes and prognostic factors in superficial spreading melanoma

Michael E. Egger, Lindsay O. Stepp, Glenda G. Callender, Amy R. Quillo, Robert C.G. Martin, Charles R. Scoggins, Arnold J. Stromberg, Kelly M. McMasters

Dr. Bing Zhang Department of Statistics

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM). Methods A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used. Results A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results. Conclusions BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.

Original language	English
Pages (from-to)	861-868
Number of pages	8
Journal	American Journal of Surgery
Volume	206
Issue number	6
DOIs	https://doi.org/10.1016/j.amjsurg.2013.09.003
State	Published - Dec 2013

Bibliographical note

Funding Information:
This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech .

Funding

This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech .

Funders	Funder number
Schering Oncology Biotech

Keywords

Lymphovascular invasion
Melanoma histology
Melanoma prognosis
Nonsentinel lymph node melanoma
Sentinel lymph node biopsy melanoma
Superficial spreading melanoma

ASJC Scopus subject areas

Surgery

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10.1016/j.amjsurg.2013.09.003

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@article{9283a61ddd384acca3aa7ad54f5a44ec,

title = "Outcomes and prognostic factors in superficial spreading melanoma",

abstract = "Background Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM). Methods A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used. Results A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results. Conclusions BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.",

keywords = "Lymphovascular invasion, Melanoma histology, Melanoma prognosis, Nonsentinel lymph node melanoma, Sentinel lymph node biopsy melanoma, Superficial spreading melanoma",

author = "Egger, \{Michael E.\} and Stepp, \{Lindsay O.\} and Callender, \{Glenda G.\} and Quillo, \{Amy R.\} and Martin, \{Robert C.G.\} and Scoggins, \{Charles R.\} and Stromberg, \{Arnold J.\} and McMasters, \{Kelly M.\}",

note = "Funding Information: This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech . ",

year = "2013",

month = dec,

doi = "10.1016/j.amjsurg.2013.09.003",

language = "English",

volume = "206",

pages = "861--868",

number = "6",

}

TY - JOUR

T1 - Outcomes and prognostic factors in superficial spreading melanoma

AU - Egger, Michael E.

AU - Stepp, Lindsay O.

AU - Callender, Glenda G.

AU - Quillo, Amy R.

AU - Martin, Robert C.G.

AU - Scoggins, Charles R.

AU - Stromberg, Arnold J.

AU - McMasters, Kelly M.

N1 - Funding Information: This study is in part a review of data from the Sunbelt Melanoma Trial, which was funded in part by a grant from Schering Oncology Biotech .

PY - 2013/12

Y1 - 2013/12

N2 - Background Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM). Methods A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used. Results A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results. Conclusions BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.

AB - Background Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM). Methods A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used. Results A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results. Conclusions BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.

KW - Lymphovascular invasion

KW - Melanoma histology

KW - Melanoma prognosis

KW - Nonsentinel lymph node melanoma

KW - Sentinel lymph node biopsy melanoma

KW - Superficial spreading melanoma

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Outcomes and prognostic factors in superficial spreading melanoma

Abstract

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Keywords

ASJC Scopus subject areas

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