Outcomes of Lung Transplantation for Cystic Fibrosis in the Setting of Extensively Drug-Resistant Organisms

Ryan J. Winstead, Georgina Waldman, Elizabeth B. Autry, Rickey A. Evans, Aric Schadler, Lindsey Kays, Maher Baz, Michael I. Anstead, Alexis Shafii, Megan E. Goetz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Introduction: Since the largest study on extensively drug-resistant organisms and lung transplantation in patients with cystic fibrosis, there have been innovations and advancements in the treatment of Pseudomonas aeruginosa. Research Question: What differences exist for patients with cystic fibrosis with a history of extensively drug-resistant infections who undergo lung transplantation despite treatment advances with antimicrobial therapy? Study Design: Two-center, retrospective, cohort study conducted in 44 patients with cystic fibrosis chronically infected with extensively drug-resistant organisms who received a lung transplant from January 2008 through August 2016. Patients in the resistant cohort were chronically infected with pan-resistant P aeruginosa, polymyxin-sensitive only, or sensitive to 2 antibiotic classes (polymyxin plus one other); remaining patients with more susceptible P aeruginosa or no P aeruginosa remained in the control cohort. The primary outcome is a composite of patient survival, retransplantation, chronic lung allograft dysfunction, and acute rejection 12 months posttransplant. Categorical variables were analyzed using χ2 testing. The independent samples t test was utilized for continuous variables. Results: There was no difference in the primary outcome (40% vs 37%, P =.831). Differences between patient survival (84% vs 95%, P =.487), the incidence of acute rejection (20% vs 33%, P =.323), and the incidence of chronic lung allograft rejection (12% vs 5%, P =.441) were not different between groups. Discussion: Recipients chronically infected with an extensively resistant P aeruginosa had similar outcomes compared to those infected with more sensitive organisms.

Original languageEnglish
Pages (from-to)220-224
Number of pages5
JournalProgress in Transplantation
Issue number3
StatePublished - Sep 1 2019

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Publisher Copyright:
© 2019, NATCO.


  • cystic fibrosis
  • lung transplant
  • multidrug resistant

ASJC Scopus subject areas

  • Transplantation


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