Outcomes of patients with differentiated thyroid carcinoma following initial therapy

Jacqueline Jonklaas, Nicholas J. Sarlis, Danielle Litofsky, Kenneth B. Ain, S. Thomas Bigos, James D. Brierley, David S. Cooper, Bryan R. Haugen, Paul W. Ladenson, James Magner, Jacob Robbins, Douglas S. Ross, Monica Skarulis, Harry R. Maxon, Steven I. Sherman

Research output: Contribution to journalArticlepeer-review

560 Scopus citations


This analysis was performed to determine the effect of initial therapy on the outcomes of thyroid cancer patients. The study setting was a prospectively followed multi-institutional registry. Patients were stratified as low risk (stages I and II) or high risk (stages III and IV). Treatments employed included near-total thyroidectomy, administration of radioactive iodine, and thyroid hormone suppression therapy. Outcome measures were overall survival, disease-specific survival, and disease-free survival. Near-total thyroidectomy, radioactive iodine, and aggressive thyroid hormone suppression therapy were each independently associated with longer overall survival in high-risk patients. Near-total thyroidectomy followed by radioactive iodine therapy, and moderate thyroid hormone suppression therapy, both predicted improved overall survival in stage II patients. No treatment modality, including lack of radioactive iodine, was associated with altered survival in stage I patients. Based on our overall survival data, we confirm that near-total thyroidectomy is indicated in high-risk patients. We also conclude that radioactive iodine therapy is beneficial for stage II, III, and IV patients. Importantly, we show for the first time that superior outcomes are associated with aggressive thyroid hormone suppression therapy in high-risk patients, but are achieved with modest suppression in stage II patients. We were unable to show any impact, positive or negative, of specific therapies in stage I patients.

Original languageEnglish
Pages (from-to)1229-1242
Number of pages14
Issue number12
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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