Ovarian cancer screening effectiveness: A realization from the UK collaborative trial of ovarian cancer screening

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

Effects on survival in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) was reported in The Lancet, and demonstrate that reductions in disease-specific mortality in this randomized control trial (RCT) indicate that ovarian cancer screening works. The UKCTOCS was large enough for sufficient accrual and follow-up, using two intervention arms: MMS (a multimodal strategy using the biomarker Ca125 combined with ultrasound as a secondary test) and USS (ultrasound alone) compared against a no-screen control group. MMS and USS performed similarly, showing a statistically significant reduction in mortality that increased with follow-up surveillance (8% reduction in years 0–7 vs 28% in years 7–14). The data led to the estimate that 641 screens are needed to prevent one ovarian cancer death.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalWomen's Health
Volume12
Issue number5
DOIs
StatePublished - Sep 2016

Bibliographical note

Publisher Copyright:
© The Author(s) 2016.

Keywords

  • Efficacy
  • Mortality reduction
  • Ovarian cancer screening
  • Potential for effectiveness
  • Ultrasound

ASJC Scopus subject areas

  • Medicine (all)

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