Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs; Brook A. Saunders; Rachel W. Miller; Scott T. Goodrich; Monica S. King; Kimberly D. Kimbler; Adam J. Branscum; Eric T. Fung; Paul D. Depriest; John R. Van Nagell; Frederick R. Ueland; Andre T. Baron

doi:10.3109/07357907.2013.802799

Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs, Brook A. Saunders, Rachel W. Miller, Scott T. Goodrich, Monica S. King, Kimberly D. Kimbler, Adam J. Branscum, Eric T. Fung, Paul D. Depriest, John R. Van Nagell, Frederick R. Ueland, Andre T. Baron

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

Original language	English
Pages (from-to)	433-453
Number of pages	21
Journal	Cancer Investigation
Volume	31
Issue number	7
DOIs	https://doi.org/10.3109/07357907.2013.802799
State	Published - Aug 2013

Bibliographical note

Funding Information:
This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

Keywords

Cancer Biomarkers
Detection/Diagnosis
Ovarian Cancer
Protein Profiling
Tumor Cell Biology

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07357907.2013.802799

Cite this

Skaggs, H. S., Saunders, B. A., Miller, R. W., Goodrich, S. T., King, M. S., Kimbler, K. D., Branscum, A. J., Fung, E. T., Depriest, P. D., Van Nagell, J. R., Ueland, F. R., & Baron, A. T. (2013). Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms. Cancer Investigation, 31(7), 433-453. https://doi.org/10.3109/07357907.2013.802799

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title = "Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms",

abstract = "SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.",

keywords = "Cancer Biomarkers, Detection/Diagnosis, Ovarian Cancer, Protein Profiling, Tumor Cell Biology",

author = "Skaggs, {Hollie S.} and Saunders, {Brook A.} and Miller, {Rachel W.} and Goodrich, {Scott T.} and King, {Monica S.} and Kimbler, {Kimberly D.} and Branscum, {Adam J.} and Fung, {Eric T.} and Depriest, {Paul D.} and {Van Nagell}, {John R.} and Ueland, {Frederick R.} and Baron, {Andre T.}",

note = "Funding Information: This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip{\textcopyright}R arrays and reagents, and access to a ProteinChip{\textcopyright}R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.",

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doi = "10.3109/07357907.2013.802799",

language = "English",

volume = "31",

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AU - Skaggs, Hollie S.

AU - Saunders, Brook A.

AU - Miller, Rachel W.

AU - Goodrich, Scott T.

AU - King, Monica S.

AU - Kimbler, Kimberly D.

AU - Branscum, Adam J.

AU - Fung, Eric T.

AU - Depriest, Paul D.

AU - Van Nagell, John R.

AU - Ueland, Frederick R.

AU - Baron, Andre T.

N1 - Funding Information: This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.

PY - 2013/8

Y1 - 2013/8

N2 - SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

AB - SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

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KW - Detection/Diagnosis

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KW - Protein Profiling

KW - Tumor Cell Biology

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Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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