Ovarian cyst fluids are a cache of tumor biomarkers that include calgranulin A and calgranulin B isoforms

Hollie S. Skaggs, Brook A. Saunders, Rachel W. Miller, Scott T. Goodrich, Monica S. King, Kimberly D. Kimbler, Adam J. Branscum, Eric T. Fung, Paul D. Depriest, John R. Van Nagell, Frederick R. Ueland, Andre T. Baron

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

Original languageEnglish
Pages (from-to)433-453
Number of pages21
JournalCancer Investigation
Issue number7
StatePublished - Aug 2013

Bibliographical note

Funding Information:
This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.


  • Cancer Biomarkers
  • Detection/Diagnosis
  • Ovarian Cancer
  • Protein Profiling
  • Tumor Cell Biology

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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