Abstract
SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 433-453 |
| Number of pages | 21 |
| Journal | Cancer Investigation |
| Volume | 31 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 2013 |
Bibliographical note
Funding Information:This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.
Funding
This research was supported by development funds from the University of Kentucky, Division of Gynecologic Oncology; Ladies for Life Foundation; and Vermillion, Inc., which provided technical support, ProteinChip©R arrays and reagents, and access to a ProteinChip©R Reader Series 4000 mass spectrometer through a research agreement with the University of Kentucky.
| Funders | Funder number |
|---|---|
| Division of Gynecologic Oncology | |
| Ladies for Life Foundation | |
| Vermillion Inc. | |
| University of Kentucky |
Keywords
- Cancer Biomarkers
- Detection/Diagnosis
- Ovarian Cancer
- Protein Profiling
- Tumor Cell Biology
ASJC Scopus subject areas
- Oncology
- Cancer Research
