Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone

Tory A. Eisenlohr-Moul; C. Nathan DeWall; Susan S. Girdler; Suzanne C. Segerstrom

doi:10.1016/j.biopsycho.2015.03.016

Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone

Tory A. Eisenlohr-Moul, C. Nathan DeWall, Susan S. Girdler, Suzanne C. Segerstrom

Psychology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Cyclical fluctuations in the ovarian hormones 17β-estradiol (E2; estrogen) and progesterone (P4) predict emotions, cognitive processes, and behaviors relevant to Borderline Personality Disorder (BPD); however, there are individual differences in sensitivity to normal hormone shifts. This study examined associations of naturally occurring hormonal changes with concurrent BPD feature expression. Forty women sampled for a flat distribution of the PAI-BOR (. n=. 10 where T<. 50, n=. 10 where 50. <. T<. 60, n=. 10 where 60. <. T<. 70, and n=. 10 where T>. 70) provided four weekly saliva samples and psychological assessments. Across most outcomes (e.g., BPD features, felt rejection, anger rumination, negative urgency) P4 deviation (from one's person mean) moderated the effect of current E2 deviation (from one's person mean) among women high (+1 SD) in trait BPD features such that E2 deviation was negatively associated with symptoms only when P4 was higher-than-usual. Cyclical hormone changes (e.g., higher P4 in the luteal phase; E2 fluctuations at ovulation and in the luteal phase) may impact BPD feature expression among at-risk women.

Original language	English
Pages (from-to)	37-52
Number of pages	16
Journal	Biological Psychology
Volume	109
DOIs	https://doi.org/10.1016/j.biopsycho.2015.03.016
State	Published - Jul 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Funding

This work was supported by grants from the National Institute of Mental Health ( T32MH093315 ), the National Institute on Drug Abuse ( DA005312 ), and the National Center for Advancing Translational Sciences ( UL1RR033173 , UL1TR000117 ). Additionally, the authors wish to thank Jessica R. Peters, Erin C. Walsh, and Kaitlyn Chamberlain for their important contributions to data collection, as well as Jennifer L. Gordon for her helpful comments on an earlier draft of this manuscript.

Funders	Funder number
National Institute of Mental Health	T32MH093315
National Institute of Mental Health
National Institute on Drug Abuse	DA005312
National Institute on Drug Abuse
National Center for Research Resources	UL1RR033173
National Center for Research Resources
National Center for Advancing Translational Sciences (NCATS)	UL1TR000117
National Center for Advancing Translational Sciences (NCATS)

Keywords

17β-estradiol
Anger rumination
Borderline personality disorder
Estrogen
Menstrual cycle
Negative urgency
Progesterone
Rejection sensitivity

ASJC Scopus subject areas

General Neuroscience
Neuropsychology and Physiological Psychology

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10.1016/j.biopsycho.2015.03.016

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title = "Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone",

abstract = "Cyclical fluctuations in the ovarian hormones 17β-estradiol (E2; estrogen) and progesterone (P4) predict emotions, cognitive processes, and behaviors relevant to Borderline Personality Disorder (BPD); however, there are individual differences in sensitivity to normal hormone shifts. This study examined associations of naturally occurring hormonal changes with concurrent BPD feature expression. Forty women sampled for a flat distribution of the PAI-BOR (. n=. 10 where T<. 50, n=. 10 where 50. <. T<. 60, n=. 10 where 60. <. T<. 70, and n=. 10 where T>. 70) provided four weekly saliva samples and psychological assessments. Across most outcomes (e.g., BPD features, felt rejection, anger rumination, negative urgency) P4 deviation (from one's person mean) moderated the effect of current E2 deviation (from one's person mean) among women high (+1 SD) in trait BPD features such that E2 deviation was negatively associated with symptoms only when P4 was higher-than-usual. Cyclical hormone changes (e.g., higher P4 in the luteal phase; E2 fluctuations at ovulation and in the luteal phase) may impact BPD feature expression among at-risk women.",

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author = "Eisenlohr-Moul, \{Tory A.\} and DeWall, \{C. Nathan\} and Girdler, \{Susan S.\} and Segerstrom, \{Suzanne C.\}",

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year = "2015",

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doi = "10.1016/j.biopsycho.2015.03.016",

language = "English",

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AU - Segerstrom, Suzanne C.

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KW - Rejection sensitivity

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Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone

Abstract

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Funding

Keywords

ASJC Scopus subject areas

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