TY - JOUR
T1 - Ovarian Sympathectomy in the Golden Hamster
T2 - Effects on Estrous Cyclicity and Follicular Development
AU - Curry, T. E.
AU - Lawrence, I. E.
AU - Burden, H. W.
PY - 1985/12
Y1 - 1985/12
N2 - The role of adrenergic nerves in estrous cyclicity and follicular growth was studied in sympathectomized hamster ovaries. Specific ovarian sympathectomy was accomplished by injection of 6-hydroxydopamine (6-OHDA) into the ovarian bursal sac. Ovarian sympathectomy abolished all fluorescent adrenergic nerves 4, 8 or 12 days after treatment. Bilateral ovarian sympathectomy on metestrus altered the first estrous cycle in 53% of the animals and 20% had an altered second cycle. All sham injected animals had normal cycles. Four days after sympathectomy, there was a decrease in healthy follicles 80240 m and 250340 m in diameter and increased atresia of follicles 80240 m and 350440 m in diameter compared to solvent treated ovaries. Bilateral 6-OHDA treatment did not affect ovarian weight, number of corpora lutea or the total number of follicles per ovary. These observations suggest that ovarian adrenergic nerves modulate healthy follicular development in the golden hamster.
AB - The role of adrenergic nerves in estrous cyclicity and follicular growth was studied in sympathectomized hamster ovaries. Specific ovarian sympathectomy was accomplished by injection of 6-hydroxydopamine (6-OHDA) into the ovarian bursal sac. Ovarian sympathectomy abolished all fluorescent adrenergic nerves 4, 8 or 12 days after treatment. Bilateral ovarian sympathectomy on metestrus altered the first estrous cycle in 53% of the animals and 20% had an altered second cycle. All sham injected animals had normal cycles. Four days after sympathectomy, there was a decrease in healthy follicles 80240 m and 250340 m in diameter and increased atresia of follicles 80240 m and 350440 m in diameter compared to solvent treated ovaries. Bilateral 6-OHDA treatment did not affect ovarian weight, number of corpora lutea or the total number of follicles per ovary. These observations suggest that ovarian adrenergic nerves modulate healthy follicular development in the golden hamster.
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U2 - 10.1055/s-0029-1210498
DO - 10.1055/s-0029-1210498
M3 - Article
C2 - 3937742
AN - SCOPUS:0022345902
SN - 0947-7349
VL - 86
SP - 284
EP - 290
JO - Experimental and Clinical Endocrinology and Diabetes
JF - Experimental and Clinical Endocrinology and Diabetes
ER -
