Ovarian Sympathectomy in the Golden Hamster: Effects on Estrous Cyclicity and Follicular Development

T. E. Curry, I. E. Lawrence, H. W. Burden

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The role of adrenergic nerves in estrous cyclicity and follicular growth was studied in sympathectomized hamster ovaries. Specific ovarian sympathectomy was accomplished by injection of 6-hydroxydopamine (6-OHDA) into the ovarian bursal sac. Ovarian sympathectomy abolished all fluorescent adrenergic nerves 4, 8 or 12 days after treatment. Bilateral ovarian sympathectomy on metestrus altered the first estrous cycle in 53% of the animals and 20% had an altered second cycle. All sham injected animals had normal cycles. Four days after sympathectomy, there was a decrease in healthy follicles 80240 m and 250340 m in diameter and increased atresia of follicles 80240 m and 350440 m in diameter compared to solvent treated ovaries. Bilateral 6-OHDA treatment did not affect ovarian weight, number of corpora lutea or the total number of follicles per ovary. These observations suggest that ovarian adrenergic nerves modulate healthy follicular development in the golden hamster.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalExperimental and Clinical Endocrinology and Diabetes
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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