TY - JOUR
T1 - Overweight Individuals Are at Increased Risk for Thrombotic Thrombocytopenic Purpura
AU - Nicol, Kathleen K.
AU - Shelton, Brent J.
AU - Knovich, Mary Ann
AU - Owen, John
PY - 2003/11
Y1 - 2003/11
N2 - Our understanding of the pathophysiology of thrombotic thrombocytopenic purpura, TTP, has increased dramatically in the past few years with the identification of the role of ADAMTS13. Nonetheless, risk factors for the development of acute TTP are few. Informally, obesity was felt to be common in patients with TTP and so a formal study was undertaken to further define this association. We report our data in 105 patients with classical TTP as defined by thrombocytopenia and microangiopathic hemolytic anemia. We found that marked obesity is a previously unrecognized risk factor with an associated odds ratio of 7.6. Interestingly, despite this increased risk, obesity might well be associated with lower mortality, although this did not reach statistical significance.
AB - Our understanding of the pathophysiology of thrombotic thrombocytopenic purpura, TTP, has increased dramatically in the past few years with the identification of the role of ADAMTS13. Nonetheless, risk factors for the development of acute TTP are few. Informally, obesity was felt to be common in patients with TTP and so a formal study was undertaken to further define this association. We report our data in 105 patients with classical TTP as defined by thrombocytopenia and microangiopathic hemolytic anemia. We found that marked obesity is a previously unrecognized risk factor with an associated odds ratio of 7.6. Interestingly, despite this increased risk, obesity might well be associated with lower mortality, although this did not reach statistical significance.
KW - Obesity
KW - TTP
KW - Weight
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U2 - 10.1002/ajh.10418
DO - 10.1002/ajh.10418
M3 - Article
C2 - 14587043
AN - SCOPUS:0242361659
SN - 0361-8609
VL - 74
SP - 170
EP - 174
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 3
ER -