Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

Carmen Méndez, Eva Künzel, Fredilyn Lipata, Felipe Lombó, William Cotham, Michael Walla, Daniel W. Bearden, Alfredo F. Braña, Jose A. Salas, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R-M- as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

Original languageEnglish
Pages (from-to)779-782
Number of pages4
JournalJournal of Natural Products
Volume65
Issue number5
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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