Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

Carmen Méndez; Eva Künzel; Fredilyn Lipata; Felipe Lombó; William Cotham; Michael Walla; Daniel W. Bearden; Alfredo F. Braña; Jose A. Salas; Jürgen Rohr

doi:10.1021/np010555n

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

Carmen Méndez
, Eva Künzel
, Fredilyn Lipata
, Felipe Lombó
, William Cotham
, Michael Walla
, Daniel W. Bearden
, Alfredo F. Braña
, Jose A. Salas
, Jürgen Rohr

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R-M- as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

Original language	English
Pages (from-to)	779-782
Number of pages	4
Journal	Journal of Natural Products
Volume	65
Issue number	5
DOIs	https://doi.org/10.1021/np010555n
State	Published - 2002

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010555n

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title = "Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891",

abstract = "Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R-M- as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.",

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doi = "10.1021/np010555n",

language = "English",

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T1 - Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

AU - Méndez, Carmen

AU - Künzel, Eva

AU - Lipata, Fredilyn

AU - Lombó, Felipe

AU - Cotham, William

AU - Walla, Michael

AU - Bearden, Daniel W.

AU - Braña, Alfredo F.

AU - Salas, Jose A.

AU - Rohr, Jürgen

PY - 2002

Y1 - 2002

N2 - Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R-M- as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

AB - Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R-M- as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

UR - https://www.scopus.com/pages/publications/0036091676

UR - https://www.scopus.com/pages/publications/0036091676#tab=citedBy

U2 - 10.1021/np010555n

DO - 10.1021/np010555n

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AN - SCOPUS:0036091676

SN - 0163-3864

VL - 65

SP - 779

EP - 782

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

Abstract

ASJC Scopus subject areas

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