Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR).
|Number of pages||6|
|Journal||Journal of Organic Chemistry|
|State||Published - Aug 9 2002|
ASJC Scopus subject areas
- Organic Chemistry