Abstract
Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR).
Original language | English |
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Pages (from-to) | 5727-5732 |
Number of pages | 6 |
Journal | Journal of Organic Chemistry |
Volume | 67 |
Issue number | 16 |
DOIs | |
State | Published - Aug 9 2002 |
ASJC Scopus subject areas
- Organic Chemistry