Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications

Suvara Kimnite Wattanapitayakul; John Anthony Bauer

doi:10.1016/S0163-7258(00)00114-5

Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications

Suvara Kimnite Wattanapitayakul, John Anthony Bauer

Pediatrics

Research output: Contribution to journal › Review article › peer-review

201 Scopus citations

Abstract

Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of mechanisms involved in disease progress. Many studies conducted in the last decade have illustrated increased biological oxidative pathways during CVD in animals and humans. Thus, increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this review we address the following questions: Do oxidative mechanisms play a role in CVD? Where do the oxidants come from? What are the relevant oxidative events? What are the therapeutic implications?

Original language	English
Pages (from-to)	187-206
Number of pages	20
Journal	Pharmacology and Therapeutics
Volume	89
Issue number	2
DOIs	https://doi.org/10.1016/S0163-7258(00)00114-5
State	Published - 2001

Bibliographical note

Funding Information:
This work was supported in part by a Research Fellowship from the Royal Thai Government (S. K. W.) and grants from the American Heart Association, Ohio-West Virginia Affiliates, and the National Institutes of Health (HL59791, DK55053, and HL63067).

Keywords

Antioxidants
Cardiovascular disease
Nitric oxide
Oxidants
Peroxynitrite
Reactive oxygen species

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0163-7258(00)00114-5

Cite this

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title = "Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications",

abstract = "Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of mechanisms involved in disease progress. Many studies conducted in the last decade have illustrated increased biological oxidative pathways during CVD in animals and humans. Thus, increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this review we address the following questions: Do oxidative mechanisms play a role in CVD? Where do the oxidants come from? What are the relevant oxidative events? What are the therapeutic implications?",

keywords = "Antioxidants, Cardiovascular disease, Nitric oxide, Oxidants, Peroxynitrite, Reactive oxygen species",

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note = "Funding Information: This work was supported in part by a Research Fellowship from the Royal Thai Government (S. K. W.) and grants from the American Heart Association, Ohio-West Virginia Affiliates, and the National Institutes of Health (HL59791, DK55053, and HL63067).",

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AU - Wattanapitayakul, Suvara Kimnite

AU - Bauer, John Anthony

N1 - Funding Information: This work was supported in part by a Research Fellowship from the Royal Thai Government (S. K. W.) and grants from the American Heart Association, Ohio-West Virginia Affiliates, and the National Institutes of Health (HL59791, DK55053, and HL63067).

PY - 2001

Y1 - 2001

N2 - Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of mechanisms involved in disease progress. Many studies conducted in the last decade have illustrated increased biological oxidative pathways during CVD in animals and humans. Thus, increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this review we address the following questions: Do oxidative mechanisms play a role in CVD? Where do the oxidants come from? What are the relevant oxidative events? What are the therapeutic implications?

AB - Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of mechanisms involved in disease progress. Many studies conducted in the last decade have illustrated increased biological oxidative pathways during CVD in animals and humans. Thus, increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this review we address the following questions: Do oxidative mechanisms play a role in CVD? Where do the oxidants come from? What are the relevant oxidative events? What are the therapeutic implications?

KW - Antioxidants

KW - Cardiovascular disease

KW - Nitric oxide

KW - Oxidants

KW - Peroxynitrite

KW - Reactive oxygen species

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Oxidative pathways in cardiovascular disease: Roles, mechanisms, and therapeutic implications

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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