Oxidative stress and chromium(VI) carcinogenesis

Hua Yao, Lan Guo, Bing Hua Jiang, Jia Luo, Xianglin Shi

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Cr(VI)-containing compounds are known carcinogens that are present in industrial settings and in the environment. The biological mechanisms responsible for the initiation and pregression of diseases resulting from exposure to Cr(VI) are not fully understood. In the last two decades, there has been increasing evidence of the correlation between Cr(VI)-induced generation of reactive oxygen species and carcinogenic actions. This article summarizes the current literature on Cr(VI)-induced generation in various chemical and biological systems. This article also covers the relationship between Cr(VI)-induced oxidative stress and activation of transcription factors NF-κB, AP-1, p53, and hypoxia-inducible factor 1, regulation of cell cycle, and induction of apoptosis.

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalJournal of Environmental Pathology, Toxicology and Oncology
Issue number2
StatePublished - 2008


  • Carcinogenesis
  • Cr(VI)
  • Oxidative stress
  • Signal transduction

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis


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