Oxidative stress and metal carcinogenesis

Jeong Chae Lee, Young Ok Son, Poyil Pratheeshkumar, Xianglin Shi

Research output: Contribution to journalReview articlepeer-review

227 Scopus citations


Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

Original languageEnglish
Pages (from-to)742-757
Number of pages16
JournalFree Radical Biology and Medicine
Issue number4
StatePublished - Aug 15 2012

Bibliographical note

Funding Information:
This work was supported in part by National Institute grants (1R01ES015518, 1R01ES017244, 2R01AA015407, and 1R01ES017244).


  • Carcinogenesis
  • Metals
  • Reactive oxygen species
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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