Oxidative stress and metal carcinogenesis

Jeong Chae Lee; Young Ok Son; Poyil Pratheeshkumar; Xianglin Shi

doi:10.1016/j.freeradbiomed.2012.06.002

Oxidative stress and metal carcinogenesis

Jeong Chae Lee, Young Ok Son, Poyil Pratheeshkumar, Xianglin Shi

Toxicology and Cancer Biology

Research output: Contribution to journal › Review article › peer-review

240 Scopus citations

Abstract

Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

Original language	English
Pages (from-to)	742-757
Number of pages	16
Journal	Free Radical Biology and Medicine
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/j.freeradbiomed.2012.06.002
State	Published - Aug 15 2012

Bibliographical note

Funding Information:
This work was supported in part by National Institute grants (1R01ES015518, 1R01ES017244, 2R01AA015407, and 1R01ES017244).

Keywords

Carcinogenesis
Metals
Reactive oxygen species
Signal transduction

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.freeradbiomed.2012.06.002

Cite this

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title = "Oxidative stress and metal carcinogenesis",

abstract = "Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.",

keywords = "Carcinogenesis, Metals, Reactive oxygen species, Signal transduction",

author = "Lee, {Jeong Chae} and Son, {Young Ok} and Poyil Pratheeshkumar and Xianglin Shi",

note = "Funding Information: This work was supported in part by National Institute grants (1R01ES015518, 1R01ES017244, 2R01AA015407, and 1R01ES017244).",

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doi = "10.1016/j.freeradbiomed.2012.06.002",

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AU - Lee, Jeong Chae

AU - Son, Young Ok

AU - Pratheeshkumar, Poyil

AU - Shi, Xianglin

N1 - Funding Information: This work was supported in part by National Institute grants (1R01ES015518, 1R01ES017244, 2R01AA015407, and 1R01ES017244).

PY - 2012/8/15

Y1 - 2012/8/15

N2 - Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

AB - Occupational and environmental exposures to metals are closely associated with an increased risk of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the exact mechanisms of action are still unclear. Accumulating evidence indicates that reactive oxygen species (ROS) generated by metals play important roles in the etiology of degenerative and chronic diseases. This review covers recent advances in (1) metal-induced generation of ROS and the related mechanisms; (2) the relationship between metal-mediated ROS generation and carcinogenesis; and (3) the signaling proteins involved in metal-induced carcinogenesis, especially intracellular reduction-oxidation-sensitive molecules.

KW - Carcinogenesis

KW - Metals

KW - Reactive oxygen species

KW - Signal transduction

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DO - 10.1016/j.freeradbiomed.2012.06.002

M3 - Review article

C2 - 22705365

AN - SCOPUS:84864408817

SN - 0891-5849

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JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

IS - 4

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Oxidative stress and metal carcinogenesis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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