Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics

D. Allan Butterfield, Marzia Perluigi, Rukhsana Sultana

Research output: Contribution to journalReview articlepeer-review

313 Scopus citations

Abstract

Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's disease is defined by the accumulation of extracellular amyloid protein deposited senile plaques and intracellular neurofibrillary tangles made of abnormal and hyperphosphorylated tau protein, regionalized neuronal death, and loss of synaptic connections within selective brain regions. Evidence has suggested a critical role for amyloid-β peptide metabolism and oxidative stress in Alzheimer's disease pathogenesis and progression. Among the other indices of oxidative stress in Alzheimer's disease brain are protein carbonyls and 3-nitrotyrosine, which are the markers of protein oxidation. Thus, in this review, we discuss the application of redox proteomics for the identification of oxidatively modified proteins in Alzheimer's disease brain and also discuss the functions associated with the identified oxidized proteins in relation to Alzheimer's disease pathology. The information obtained from proteomics may be helpful in understanding the molecular mechanisms involved in the development and progression of Alzheimer's disease as well as of other neurodegenerative disorders. Further, redox proteomics may provide potential targets for drug therapy in Alzheimer's disease.

Original languageEnglish
Pages (from-to)39-50
Number of pages12
JournalEuropean Journal of Pharmacology
Volume545
Issue number1
DOIs
StatePublished - Sep 1 2006

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Institute of Health to D.A.B. [AG-05119; AG-10836].

Keywords

  • Alzheimer's disease
  • Hippocampus
  • Inferior parietal lobule
  • Oxidative stress
  • Protein oxidation
  • Redox proteomics

ASJC Scopus subject areas

  • Pharmacology

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