Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.

Original languageEnglish
Article number462
Issue number2
StatePublished - Feb 2023

Bibliographical note

Publisher Copyright:
© 2023 by the author.


  • Abeta and oxidative stress
  • key metabolic pathways involved in MCI
  • lipid peroxidation
  • neuronal loss
  • potential therapeutic strategies for MCI

ASJC Scopus subject areas

  • Food Science
  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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