Abstract
Amnestic mild cognitive impairment (MCI), arguably the earliest clinical stage of Alzheimer disease (AD), is characterized by normal activities of daily living but with memory issues but no dementia. Oxidative stress, with consequent damaged key proteins and lipids, are prominent even in this early state of AD. This review article outlines oxidative stress in MCI and how this can account for neuronal loss and potential therapeutic strategies to slow progression to AD.
| Original language | English |
|---|---|
| Article number | 462 |
| Journal | Antioxidants |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2023 |
Bibliographical note
Publisher Copyright:© 2023 by the author.
Funding
This work was supported in part by a grant from the National Institute on Aging [AG060056].
| Funders | Funder number |
|---|---|
| National Institute on Aging | AG060056 |
| National Institute on Aging |
Keywords
- Abeta and oxidative stress
- key metabolic pathways involved in MCI
- lipid peroxidation
- neuronal loss
- potential therapeutic strategies for MCI
ASJC Scopus subject areas
- Food Science
- Physiology
- Biochemistry
- Molecular Biology
- Clinical Biochemistry
- Cell Biology