Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes

Cetewayo S. Rashid; Amita Bansal; Rebecca A. Simmons

doi:10.1152/physiol.00023.2018

Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes

Cetewayo S. Rashid, Amita Bansal, Rebecca A. Simmons

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.

Original language	English
Pages (from-to)	348-359
Number of pages	12
Journal	Physiology
Volume	33
Issue number	5
DOIs	https://doi.org/10.1152/physiol.00023.2018
State	Published - 2018

Bibliographical note

Funding Information:
This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK-114054.

Publisher Copyright:
© American Physiological Society. All rights reserved.

ASJC Scopus subject areas

Physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/physiol.00023.2018

Cite this

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abstract = "Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.",

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AU - Bansal, Amita

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Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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