Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes

Cetewayo S. Rashid, Amita Bansal, Rebecca A. Simmons

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.

Original languageEnglish
Pages (from-to)348-359
Number of pages12
JournalPhysiology
Volume33
Issue number5
DOIs
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© American Physiological Society. All rights reserved.

ASJC Scopus subject areas

  • Physiology

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