Oxidative stress, intrauterine growth restriction, and developmental programming of type 2 diabetes

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Intrauterine growth restriction (IUGR) leads to reduced birth weight and the development of metabolic diseases such as Type 2 diabetes in adulthood. Mitochondria dysfunction and oxidative stress are commonly found in key tissues (pancreatic islets, liver, and skeletal muscle) of IUGR individuals. In this review, we explore the role of oxidative stress in IUGR-associated diabetes etiology.

Original languageEnglish
Pages (from-to)348-359
Number of pages12
JournalPhysiology
Volume33
Issue number5
DOIs
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© American Physiological Society. All rights reserved.

Funding

This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK-114054.

FundersFunder number
National Institute of Diabetes and Digestive and Kidney DiseasesR01DK114054

    UN SDGs

    This output contributes to the following UN Sustainable Development Goals (SDGs)

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being

    ASJC Scopus subject areas

    • Physiology

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