Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and alzheimer's disease: Many pathways to neurodegeneration

D. Allan Butterfield, Sarita S. Hardas, Miranda L.Bader Lange

Research output: Contribution to journalReview articlepeer-review

219 Scopus citations

Abstract

Recently, the oxidoreductase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), has become a subject of interest as more and more studies reveal a surfeit of diverse GAPDH functions, extending beyond traditional aerobic metabolism of glucose. As a result of multiple isoforms and cellular locales, GAPDH is able to come in contact with a variety of small molecules, proteins, membranes, etc., that play important roles in normal and pathologic cell function. Specifically, GAPDH has been shown to interact with neurodegenerative disease-associated proteins, including the amyloid-β protein precursor (AβPP). Studies from our laboratory have shown significant inhibition of GAPDH dehydrogenase activity in Alzheimer's disease (AD) brain due to oxidative modification. Although oxidative stress and damage is a common phenomenon in the AD brain, it would seem that inhibition of glycolytic enzyme activity is merely one avenue in which AD pathology affects neuronal cell development and survival, as oxidative modification can also impart a toxic gain-of-function to many proteins, including GAPDH. In this review, we examine the many functions of GAPDH with respect to AD brain; in particular, the apparent role(s) of GAPDH in AD-related apoptotic cell death is emphasized.

Original languageEnglish
Pages (from-to)369-393
Number of pages25
JournalJournal of Alzheimer's Disease
Volume20
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Alzheimer's disease
  • amyloid-β
  • amyloid-β protein precursor
  • apoptosis
  • glyceraldehyde-3-phosphate dehydrogenase
  • hypometabolism
  • oxidative stress

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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