P-140. Fitness is related to 24-h GH release in older men but not women

M. L. Hartman, J. L. Clasey, J. Y. Weltman, L. Wideman, J. A. Kanaley, S. B. Freund, C. D. Teates, C. Bouchard, M. O. Thorner, A. Weltman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

24-h GH release is correlated with visceral adipose tissue (VAT) in older men and women (ICE 1996 #OR3-4). To determine the relationship among aerobic fitness, VAT and GH release in older adults, serum GH was measured (chemiluminescence assay) at 5-min internals for 24 h in 17 older and 14 women (67±0.9 [SE] yr); 24-h integrated [GH] (IGHC) was calculated. Peak oxygen consumption (VO2 peak, n = 31) and VO2 at the lactate threshold (VO2 LT, n = 19) were measured during an incremental treadmill test. VAT area was measured by CT at the L4-L5 space. Men had higher values (vs women, ml-kg-1-min-1) for VO2 peak (32.5±1.1 vs 22.8±1.2, p<0.01) and VO2 LT (21.1±1.2 vs 15.1±0.3, p<0.01). Men tended to have lower IGHC than women (664±87 vs 913±110 min μg-L-1, p = 0.08) but VAT area did not differ (123±13 vs 112±11 cm2). IGHC was correlated with VO2 peak and VO2 LT in men (r = 0.51, p = 0.04; r = 0.77, p<0.01) but not in women (r = 0.21; r = 0.08). VAT was correlated with VO2 peak and VO2 LT in men (r = 0.77, p<0.01; r = 62. p = 0.07) but not women (r = 0.35, r = 0.34). In contrast, IGHC was correlated with VAT in both men (r=0.75, p<0.01) and women (r = 0.59, P = 0.03). We conclude that in older men aerobic fitness is related to both 24-h GH release and VAT; fitness may influence GH secretion directly or by reducing VAT. In older women. 24-h GH release is related to VAT but not to aerobic fitness; fitness has less impact on VAT.

Original languageEnglish
Pages (from-to)90
Number of pages1
JournalEndocrinology and Metabolism, Supplement
Volume4
Issue numberA
StatePublished - 1997

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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