TY - JOUR
T1 - p38 Kinase is activated in the Alzheimer's disease brain
AU - Hensley, Kenneth
AU - Floyd, Robert A.
AU - Zheng, Nai Ying
AU - Nael, Raha
AU - Robinson, Kent A.
AU - Nguyen, Xuan
AU - Pye, Quentin N.
AU - Stewart, Charles A.
AU - Geddes, James
AU - Markesbery, William R.
AU - Patel, Ela
AU - Johnson, Gail V.W.
AU - Bing, Guoying
PY - 1999
Y1 - 1999
N2 - The p38 mitogen-activated protein kinase is a stress-activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age-matched normal brain. Intense phospho-p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle-bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF-positive tau did not cross-react with the phospho-p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.
AB - The p38 mitogen-activated protein kinase is a stress-activated enzyme responsible for transducing inflammatory signals and initiating apoptosis. In the Alzheimer's disease (AD) brain, increased levels of phosphorylated (active) p38 were detected relative to age-matched normal brain. Intense phospho-p38 immunoreactivity was associated with neuritic plaques, neuropil threads, and neurofibrillary tangle-bearing neurons. The antibody against phosphorylated p38 recognized many of the same structures as an antibody against aberrantly phosphorylated, paired helical filament (PHF) tau, although PHF-positive tau did not cross-react with the phospho-p38 antibody. These findings suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.
KW - Alzheimer's disease
KW - Dementia
KW - Inflammation
KW - Tau
KW - p38 kinase
UR - https://www.scopus.com/pages/publications/0033043939
UR - https://www.scopus.com/pages/publications/0033043939#tab=citedBy
U2 - 10.1046/j.1471-4159.1999.0722053.x
DO - 10.1046/j.1471-4159.1999.0722053.x
M3 - Article
C2 - 10217284
AN - SCOPUS:0033043939
SN - 0022-3042
VL - 72
SP - 2053
EP - 2058
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 5
ER -