TY - JOUR
T1 - PAMAM dendrimer based macromolecules as improved contrast agents
AU - Venditto, Vincent J.
AU - Regino, Celeste Aida S.
AU - Brechbiel, Martin W.
PY - 2005/7
Y1 - 2005/7
N2 - Dendrimers are an attractive platform for macromolecular imaging due to the presence of multiple terminal groups on the exterior of the molecule. Through application of appropriate metal ion chelates, large numbers of metal ions for imaging (paramagnetic or radioopaque) and therapy (radioactive particle emitters) may be conjugated to the dendrimer in combination with a targeting vector, through classic organic synthetic techniques. Thus, a large amount of these metal ions potentially may be site specifically delivered directly into the body with the dendrimer as the vehicle with the targeting vector directing the modified dendrimer. The development of targeted macromolecular agents with acceptable blood retention times and selective organ uptake then has the potential for various biological applications. A review of comparative studies of dendrimers with various externally appended imaging and targeting agents is presented herein.
AB - Dendrimers are an attractive platform for macromolecular imaging due to the presence of multiple terminal groups on the exterior of the molecule. Through application of appropriate metal ion chelates, large numbers of metal ions for imaging (paramagnetic or radioopaque) and therapy (radioactive particle emitters) may be conjugated to the dendrimer in combination with a targeting vector, through classic organic synthetic techniques. Thus, a large amount of these metal ions potentially may be site specifically delivered directly into the body with the dendrimer as the vehicle with the targeting vector directing the modified dendrimer. The development of targeted macromolecular agents with acceptable blood retention times and selective organ uptake then has the potential for various biological applications. A review of comparative studies of dendrimers with various externally appended imaging and targeting agents is presented herein.
KW - Biodistribution
KW - Macromolecular contrast agents
KW - Magnetic resonance imaging
KW - Molecular relaxivity
KW - PAMAM dendrimers
KW - Targeted imaging
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U2 - 10.1021/mp050019e
DO - 10.1021/mp050019e
M3 - Review article
C2 - 16053333
AN - SCOPUS:23944435903
SN - 1543-8384
VL - 2
SP - 302
EP - 311
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
IS - 4
ER -