Pancreatic Insufficiency: What Is the Gold Standard?

Maisam Abu-El-Haija; Darwin L. Conwell

doi:10.1016/j.giec.2018.05.004

Pancreatic Insufficiency: What Is the Gold Standard?

Maisam Abu-El-Haija, Darwin L. Conwell

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Endoscopic pancreatic function testing assesses exocrine insufficiency and chronic pancreatitis. Indirect pancreatic function tests have limited sensitivity and specificity in early disease stages. Magnetic resonance cholangiopancreatography shows promise in detecting early changes as a direct measure of pancreatic function. This article summarizes the evolution of pancreatic function testing and highlights areas for future research, such as development of diagnostic biomarkers to stratify disease severity and targeted therapies to retard disease progression.

Original language	English
Pages (from-to)	521-528
Number of pages	8
Journal	Gastrointestinal Endoscopy Clinics of North America
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.giec.2018.05.004
State	Published - Oct 2018

Bibliographical note

Funding Information:
Disclosures: In-kind support for investigator-initiated grant from ChiRhoClin, Inc was received for the MR study (M. Abu-El-Haija). The National Pancreas Foundation funded parts of the Pancreatic Function Studies using MRI (M. Abu-El-Haija). This study was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award number U01DK108327 (D.L. Conwell). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Chronic pancreatitis
Endoscopic function testing
Pancreatic function testing
Pancreatic insufficiency

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.giec.2018.05.004

Cite this

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title = "Pancreatic Insufficiency: What Is the Gold Standard?",

abstract = "Endoscopic pancreatic function testing assesses exocrine insufficiency and chronic pancreatitis. Indirect pancreatic function tests have limited sensitivity and specificity in early disease stages. Magnetic resonance cholangiopancreatography shows promise in detecting early changes as a direct measure of pancreatic function. This article summarizes the evolution of pancreatic function testing and highlights areas for future research, such as development of diagnostic biomarkers to stratify disease severity and targeted therapies to retard disease progression.",

keywords = "Chronic pancreatitis, Endoscopic function testing, Pancreatic function testing, Pancreatic insufficiency",

author = "Maisam Abu-El-Haija and Conwell, {Darwin L.}",

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AU - Conwell, Darwin L.

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N2 - Endoscopic pancreatic function testing assesses exocrine insufficiency and chronic pancreatitis. Indirect pancreatic function tests have limited sensitivity and specificity in early disease stages. Magnetic resonance cholangiopancreatography shows promise in detecting early changes as a direct measure of pancreatic function. This article summarizes the evolution of pancreatic function testing and highlights areas for future research, such as development of diagnostic biomarkers to stratify disease severity and targeted therapies to retard disease progression.

AB - Endoscopic pancreatic function testing assesses exocrine insufficiency and chronic pancreatitis. Indirect pancreatic function tests have limited sensitivity and specificity in early disease stages. Magnetic resonance cholangiopancreatography shows promise in detecting early changes as a direct measure of pancreatic function. This article summarizes the evolution of pancreatic function testing and highlights areas for future research, such as development of diagnostic biomarkers to stratify disease severity and targeted therapies to retard disease progression.

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KW - Pancreatic insufficiency

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Pancreatic Insufficiency: What Is the Gold Standard?

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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