Abstract
Endoscopic pancreatic function testing assesses exocrine insufficiency and chronic pancreatitis. Indirect pancreatic function tests have limited sensitivity and specificity in early disease stages. Magnetic resonance cholangiopancreatography shows promise in detecting early changes as a direct measure of pancreatic function. This article summarizes the evolution of pancreatic function testing and highlights areas for future research, such as development of diagnostic biomarkers to stratify disease severity and targeted therapies to retard disease progression.
| Original language | English |
|---|---|
| Pages (from-to) | 521-528 |
| Number of pages | 8 |
| Journal | Gastrointestinal Endoscopy Clinics of North America |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2018 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Inc.
Funding
Disclosures: In-kind support for investigator-initiated grant from ChiRhoClin, Inc was received for the MR study (M. Abu-El-Haija). The National Pancreas Foundation funded parts of the Pancreatic Function Studies using MRI (M. Abu-El-Haija). This study was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award number U01DK108327 (D.L. Conwell). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
| Funders | Funder number |
|---|---|
| Pancreatic Function Studies using MRI | |
| National Institutes of Health (NIH) | |
| National Childhood Cancer Registry – National Cancer Institute | |
| National Institute of Diabetes and Digestive and Kidney Diseases | U01DK108327 |
| National Pancreas Foundation |
Keywords
- Chronic pancreatitis
- Endoscopic function testing
- Pancreatic function testing
- Pancreatic insufficiency
ASJC Scopus subject areas
- Gastroenterology