Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

Barham K.Abu Dayyeh; Darwin Conwell; Navtej S. Buttar; Vivek Kadilaya; Philip A. Hart; Nikola A. Baumann; Benjamin L. Bick; Suresh T. Chari; Sonia Chowdhary; Jonathan E. Clain; Ferga C. Gleeson; Linda S. Lee; Michael J. Levy; Randall K. Pearson; Bret T. Petersen; Elizabeth Rajan; Hanno Steen; Shadeah Suleiman; Peter A. Banks; Santhi S. Vege; Mark Topazian

doi:10.1038/ctg.2014.23

Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

Barham K.Abu Dayyeh, Darwin Conwell, Navtej S. Buttar, Vivek Kadilaya, Philip A. Hart, Nikola A. Baumann, Benjamin L. Bick, Suresh T. Chari, Sonia Chowdhary, Jonathan E. Clain, Ferga C. Gleeson, Linda S. Lee, Michael J. Levy, Randall K. Pearson, Bret T. Petersen, Elizabeth Rajan, Hanno Steen, Shadeah Suleiman, Peter A. Banks, Santhi S. VegeMark Topazian

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objectives: Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease. Methods: We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants. Results: Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P ≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations. Conclusions: PJ PGE2 appears to be a biomarker for CP and is elevated in both established and "minimal change" chronic pancreatitis.

Original language	English
Article number	e72
Journal	Clinical and Translational Gastroenterology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/ctg.2014.23
State	Published - Jan 1 2015

Bibliographical note

Publisher Copyright:
© 2015 the American College of Gastroenterology All rights reserved.

Funding

Guarantor of the article: Mark Topazian, MD. Specific author contributions: BK Abu Dayyeh: conception and design, data analysis, drafting of the manuscript. Darwin Conwell: data collection and analysis, critical revision of the manuscript. NS Buttar: data collection and analysis, critical revision of the manuscript. PA Hart, BL Bick, ST Chari, JE Clain, FC Gleeson, MJ Levy, RK Pearson, BT Petersen, S Suleiman, PA Banks, E Rajan, SS Vege: critical revision of the manuscript. V Kadilaya: data collection. LS Lee: data collection. S Chowdhary: data collection. M Topazian: conception and design, data collection, data analysis, critical revision of the manuscript, overall study supervision. All authors: approved the final version of the manuscript. Financial support: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN; Harvard Digestive Diseases Center (DC, NIH 5 P30 DK034854-24); and NIH NIDDK (DC, 1R21 DK081703-01A2), Burrill Family Research Grant. These entities did not participate in the conception or design of the study, the analysis or interpretation of data, the writing of the manuscript, or approval of the final manuscript. Potential competing interests: None.

Funders	Funder number
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic
Harvard Digestive Diseases Center
NIH NIDDK	1R21 DK081703-01A2
National Institutes of Health (NIH)	5 P30 DK034854-24

ASJC Scopus subject areas

Gastroenterology

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Dayyeh, B. K. A., Conwell, D., Buttar, N. S., Kadilaya, V., Hart, P. A., Baumann, N. A., Bick, B. L., Chari, S. T., Chowdhary, S., Clain, J. E., Gleeson, F. C., Lee, L. S., Levy, M. J., Pearson, R. K., Petersen, B. T., Rajan, E., Steen, H., Suleiman, S., Banks, P. A., ... Topazian, M. (2015). Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease. Clinical and Translational Gastroenterology, 6(1), Article e72. https://doi.org/10.1038/ctg.2014.23

@article{040ea411ac2b421290fa65a736a17c38,

title = "Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease",

abstract = "Objectives: Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease. Methods: We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for {"}minimal change{"} chronic pancreatitis (MCCP), and 10 normal control participants. Results: Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P ≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations. Conclusions: PJ PGE2 appears to be a biomarker for CP and is elevated in both established and {"}minimal change{"} chronic pancreatitis.",

author = "Dayyeh, {Barham K.Abu} and Darwin Conwell and Buttar, {Navtej S.} and Vivek Kadilaya and Hart, {Philip A.} and Baumann, {Nikola A.} and Bick, {Benjamin L.} and Chari, {Suresh T.} and Sonia Chowdhary and Clain, {Jonathan E.} and Gleeson, {Ferga C.} and Lee, {Linda S.} and Levy, {Michael J.} and Pearson, {Randall K.} and Petersen, {Bret T.} and Elizabeth Rajan and Hanno Steen and Shadeah Suleiman and Banks, {Peter A.} and Vege, {Santhi S.} and Mark Topazian",

year = "2015",

month = jan,

day = "1",

doi = "10.1038/ctg.2014.23",

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Dayyeh, BKA, Conwell, D, Buttar, NS, Kadilaya, V, Hart, PA, Baumann, NA, Bick, BL, Chari, ST, Chowdhary, S, Clain, JE, Gleeson, FC, Lee, LS, Levy, MJ, Pearson, RK, Petersen, BT, Rajan, E, Steen, H, Suleiman, S, Banks, PA, Vege, SS & Topazian, M 2015, 'Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease', Clinical and Translational Gastroenterology, vol. 6, no. 1, e72. https://doi.org/10.1038/ctg.2014.23

TY - JOUR

T1 - Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

AU - Dayyeh, Barham K.Abu

AU - Conwell, Darwin

AU - Buttar, Navtej S.

AU - Kadilaya, Vivek

AU - Hart, Philip A.

AU - Baumann, Nikola A.

AU - Bick, Benjamin L.

AU - Chari, Suresh T.

AU - Chowdhary, Sonia

AU - Clain, Jonathan E.

AU - Gleeson, Ferga C.

AU - Lee, Linda S.

AU - Levy, Michael J.

AU - Pearson, Randall K.

AU - Petersen, Bret T.

AU - Rajan, Elizabeth

AU - Steen, Hanno

AU - Suleiman, Shadeah

AU - Banks, Peter A.

AU - Vege, Santhi S.

AU - Topazian, Mark

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objectives: Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease. Methods: We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants. Results: Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P ≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations. Conclusions: PJ PGE2 appears to be a biomarker for CP and is elevated in both established and "minimal change" chronic pancreatitis.

AB - Objectives: Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease. Methods: We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants. Results: Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P ≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations. Conclusions: PJ PGE2 appears to be a biomarker for CP and is elevated in both established and "minimal change" chronic pancreatitis.

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U2 - 10.1038/ctg.2014.23

DO - 10.1038/ctg.2014.23

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JO - Clinical and Translational Gastroenterology

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M1 - e72

ER -

Pancreatic juice prostaglandin E2 concentrations are elevated in chronic pancreatitis and improve detection of early disease

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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