Pancreaticoduodenectomy outcomes in the pediatric, adolescent, and young adult population

Sara A. Mansfield, Justin B. Mahida, Mary Dillhoff, Kyle Porter, Darwin Conwell, Mark Ranalli, Jon P. Walker, Jennifer H. Aldrink

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background Pancreatic malignancy and chronic pancreatitis are rare in the pediatric, adolescent, and young adult (AYA) population, making pancreas resections an infrequent procedure in this demographic. Only case reports and small case series exist in the literature describing surgical outcomes and complications in this population. The aim of this study was to review the surgical outcomes of pediatric/AYA patients undergoing pancreaticoduodenectomy (PD) at our institution. Methods All pediatric/AYA adult patients (≤30 years) undergoing PD over a 15-year period (1998-2013) from a large academic institution were included. We provide adult (>30 years) data from our same institution for observational comparison. Retrospective chart review was performed to identify pertinent preoperative, perioperative, and postoperative data. Results Twenty-two patients with a median age of 25 years (range, 11-30 years) underwent PD. The most common postoperative histologic diagnoses were chronic pancreatitis (6, 27.3%), solid pseudopapillary neoplasm (5, 22.7%), and adenocarcinoma (4, 18.2%). Complications were 31.8% in the pediatric/AYA cohort and 58.6% in the adult cohort. The most common postoperative complication was intraabdominal abscess, which occurred in three patients (13.6%). Thirty-day mortality was 0% for pediatric/AYA patients. There were no recurrences or disease-related deaths in patients with solid pseudopapillary neoplasm. Pediatric patients with adenocarcinoma had a median survival of 10.2 mo (interquartile range, 9-21), in contrast to adults of 57.8 mo (interquartile range, 11-132). Conclusions This is the largest series of PD procedures reported in the pediatric/AYA population. The procedure appears to be safe, with no 30-day mortalities and an acceptable complication rate.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalJournal of Surgical Research
Issue number1
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.


  • Adolescent and young adult
  • Chronic pancreatitis
  • Outcomes
  • Pancreaticoduodenectomy
  • Pediatric
  • Solid pseudopapillary neoplasm

ASJC Scopus subject areas

  • Surgery


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