Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

doi:10.1053/j.gastro.2022.09.036

Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

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Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Original language	English
Pages (from-to)	289-292.e4
Journal	Gastroenterology
Volume	164
Issue number	2
DOIs	https://doi.org/10.1053/j.gastro.2022.09.036
State	Published - Feb 2023

Bibliographical note

Funding Information:
Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources , a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute ).

Funding Information:
Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute).

Funding

Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources , a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute ). Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute).

Funders	Funder number
National Institutes of Health (NIH)	U01DK108306
National Institutes of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases	DK061451, DK077906, DK063922
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Dental and Craniofacial Research	R01-DD000295, U01-DE020078, R01-DE016148, X01-HG007845, K99/R00-DE025060, R01-DE011931, R21-DE016930 DE016930, UL1 RR024153
National Institute of Dental and Craniofacial Research
National Center for Research Resources
University of Pittsburgh Cancer Institute	P30CA047904
University of Pittsburgh Cancer Institute
China Scholarship Council	201906370264
China Scholarship Council
Second Xiangya Hospital of Central South University

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1053/j.gastro.2022.09.036

Cite this

@article{c2fb9bbb2ecc437987bc3ad043bb4071,

title = "Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression",

author = "Dongni Fu and Blobner, {Brandon M.} and Greer, {Phil J.} and Robert Lafyatis and Bellin, {Melena D.} and Whitcomb, {David C.} and Greg Beilman and Brand, {Randall E.} and {Shelton Ohlsen}, Celeste and Saloman, {Jami L.} and Park, {H. J.} and Lee, {Kenneth K.} and Alessandro Paniccia and Amer Zureikat and Samer Alkaade and Stephen Amann and Anderson, {Michelle A.} and Peter Banks and Conwell, {Darwin L.} and Cote, {Gregory A.} and Forsmark, {Christopher E.} and Gardner, {Timothy B.} and Andres Gelrud and Guda, {Nalini M.} and Lewis, {Michele D.} and Thiruvengadam Muniraj and Papachristou, {Georgios I.} and Joseph Romagnuolo and Sandhu, {Bimaljit S.} and Stuart Sherman and Singh, {Vikesh K.} and Adam Slivka and {Melbern Wilcox}, Charles and Dhiraj Yadav",

note = "Funding Information: Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources , a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute ). Funding Information: Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute).",

year = "2023",

month = feb,

doi = "10.1053/j.gastro.2022.09.036",

language = "English",

volume = "164",

pages = "289--292.e4",

number = "2",

}

TY - JOUR

T1 - Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

AU - Fu, Dongni

AU - Blobner, Brandon M.

AU - Greer, Phil J.

AU - Lafyatis, Robert

AU - Bellin, Melena D.

AU - Whitcomb, David C.

AU - Beilman, Greg

AU - Brand, Randall E.

AU - Shelton Ohlsen, Celeste

AU - Saloman, Jami L.

AU - Park, H. J.

AU - Lee, Kenneth K.

AU - Paniccia, Alessandro

AU - Zureikat, Amer

AU - Alkaade, Samer

AU - Amann, Stephen

AU - Anderson, Michelle A.

AU - Banks, Peter

AU - Conwell, Darwin L.

AU - Cote, Gregory A.

AU - Forsmark, Christopher E.

AU - Gardner, Timothy B.

AU - Gelrud, Andres

AU - Guda, Nalini M.

AU - Lewis, Michele D.

AU - Muniraj, Thiruvengadam

AU - Papachristou, Georgios I.

AU - Romagnuolo, Joseph

AU - Sandhu, Bimaljit S.

AU - Sherman, Stuart

AU - Singh, Vikesh K.

AU - Slivka, Adam

AU - Melbern Wilcox, Charles

AU - Yadav, Dhiraj

N1 - Funding Information: Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources , a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute ). Funding Information: Funding Supported by the program of China Scholarships Council (no. 201906370264) and Third Xiangya Hospital of Central South University (Dongni Fu) and the National Institute of Diabetes and Digestive and Kidney Diseases DK063922 (Celeste Shelton Ohlsen) and DK061451 (David C. Whitcomb). Grants supporting GWAS consortium studies: The National Institutes of Health (NIH), including T32DK063922 (David C. Whitcomb, Celeste Shelton Ohlsen), and U01DK108306 (Dhiraj Yadav). The NAPS2 Consortium was supported by DK061451 (David C. Whitcomb) and DK077906 (Dhiraj Yadav). The Pittsburgh Controls were supported by the National Institute of Dental and Craniofacial Research (Seth M. Weinberg, U01-DE020078) and the Center for Craniofacial and Dental Genetics supported by R01-DE016148 (principal investigators [PIs] Mary L. Marazita and Seth M. Weinberg); R21-DE016930 DE016930 and X01-HG007845 (PI Mary L. Marazita); R01-DD000295 (PI George Wehby), R01-DE011931 (PI Jacqueline C. Hecht), and K99/R00-DE025060 (PI Elizabeth Jane Leslie). Additional support included The University of Pittsburgh Genomics and Proteomics Core Laboratory (supported by UL1 RR024153 from the National Center for Research Resources, a component of the NIH, and NIH Roadmap for Medical Research), the University of Pittsburgh Cancer Institute Clinical Genomics Immunoproteomics and Sequencing Facility (NIH P30CA047904 from the University of Pittsburgh Cancer Institute).

PY - 2023/2

Y1 - 2023/2

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U2 - 10.1053/j.gastro.2022.09.036

DO - 10.1053/j.gastro.2022.09.036

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AN - SCOPUS:85146017830

SN - 0016-5085

VL - 164

SP - 289-292.e4

JO - Gastroenterology

JF - Gastroenterology

IS - 2

ER -

Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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