Par-4 inducible apoptosis in prostate cancer cells

Sushma Gurumurthy, Vivek M. Rangnekar

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy.

Original languageEnglish
Pages (from-to)504-512
Number of pages9
JournalJournal of Cellular Biochemistry
Volume91
Issue number3
DOIs
StatePublished - 2004

Keywords

  • Apoptosis
  • Par-4
  • Prostate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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