Par-4 inducible apoptosis in prostate cancer cells

Sushma Gurumurthy; Vivek M. Rangnekar

doi:10.1002/jcb.20000

Par-4 inducible apoptosis in prostate cancer cells

Sushma Gurumurthy, Vivek M. Rangnekar

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy.

Original language	English
Pages (from-to)	504-512
Number of pages	9
Journal	Journal of Cellular Biochemistry
Volume	91
Issue number	3
DOIs	https://doi.org/10.1002/jcb.20000
State	Published - 2004

Keywords

Apoptosis
Par-4
Prostate

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/jcb.20000

Cite this

@article{713c7e5c94f44185b9b3dc30af02f142,

title = "Par-4 inducible apoptosis in prostate cancer cells",

abstract = "Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy.",

keywords = "Apoptosis, Par-4, Prostate",

author = "Sushma Gurumurthy and Rangnekar, {Vivek M.}",

year = "2004",

doi = "10.1002/jcb.20000",

language = "English",

volume = "91",

pages = "504--512",

number = "3",

}

TY - JOUR

T1 - Par-4 inducible apoptosis in prostate cancer cells

AU - Gurumurthy, Sushma

AU - Rangnekar, Vivek M.

PY - 2004

Y1 - 2004

N2 - Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy.

AB - Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to prostate cancer therapy.

KW - Apoptosis

KW - Par-4

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=3843127864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3843127864&partnerID=8YFLogxK

U2 - 10.1002/jcb.20000

DO - 10.1002/jcb.20000

M3 - Review article

C2 - 14755681

AN - SCOPUS:3843127864

VL - 91

SP - 504

EP - 512

IS - 3

ER -

Par-4 inducible apoptosis in prostate cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this