Paracorporeal artificial lung as a bridge to recovery or lung transplant

Joseph B. Zwischenberger, Dongfang Wang, Scott D. Lick, Scott K. Alpard, Clare Savage, Donald J. Deyo, Akhil Bidani, Sean Chambers

Research output: Contribution to journalConference articlepeer-review


A Paracorporeal Artificial Lung (PAL) was designed and built by MC3 Corporation for high gas exchange efficiency and low blood flow resistance as a bridge to recovery or lung transplant. The initial PAL implanted in a pulmonary artery-to-artery (PA-PA) configuration supported gas exchange in normal sheep (n=8) up to 7 days. 4/8 sheep survived, but 4/8 experienced right heart failure. Following modifications to lower resistance with an inflow compliance chamber, 6/7 exhibited good cardiac function and total gas exchange for 72 h. We identified several additional complications including acute massive hemothorax (2/24), late (>24 h) hemothorax (4/24), cannula kinking (2/24), and anastomotic stricture (3/24). We addressed bleeding by a heparin free window and reduced dose, changed cannulae position and used Gore-Tex reinforced graft. We then encountered no hemothorax or outflow obstruction. Using our LD100 smoke/burn ARDS sheep model, we compared PAL (n=8) to volume-controlled mechanical ventilation (VCMV, n=6) in a prospective, randomized, controlled, unblinded, outcomes study to assess outcomes. Both groups were managed with a VCMV algorithm. 6/8 PAL vs. 1/6 VCMV sheep survived the 5-day study. Next, we will study impact on survival and pathophysiology from a LD100 smoke/burn injury using injection molded PALs with biocompatible surfaces.

Original languageEnglish
Pages (from-to)1583-1584
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • ARDS
  • Artificial lung
  • Lung transplantation

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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