Parenteral safflower oil emulsion (liposyn 10%). Safety and effectiveness in treating or preventing essential fatty acid deficiency in surgical patients

B. A. Bivins, R. P. Rapp, K. Record, H. C. Meng, W. O. Griffen

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The safety and effectiveness of a 10% safflower oil emulsion in treating or preventing essential fatty acid deficiency was tested in a prospective study of 15 surgical patients requiring total parenteral nutrition for two to four weeks. Three dosage regimens were evaluated including: Group I: 4% of calories as linoleate daily (five patients), Group II: 4% of calories as linoleate every other day (two patients), and Group III: 8% of calories every other day (eight patients). Patients were monitored for laboratory changes from baseline specifically in those areas where previous fat emulsions have caused serious deviations. No significant changes were noted in hematologic parameters, coagulation studies, cholesterol and triglyceride serum levels. Although there were sporadic mild deviations in liver function changes in several patients, no clinically significant adverse effects could be directly attributed to infusion of the fat emulsion. Three patients had baseline triene/tetraene ratios of 0.4 or greater, indicative of essential fatty acid deficiency, and these ratios dropped to less than 0.4 within eight days of beginning therapy with the parenteral fat emulsion. The remaining 12 patients maintained a normal triene/tetraene ratio of less than 0.4 throughout the 28 day study period. All three dosage regimens were considered effective for treatment and prevention of essential fatty acid deficiency.

Original languageEnglish
Pages (from-to)307-315
Number of pages9
JournalAnnals of Surgery
Volume191
Issue number3
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Surgery

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