Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats

L. J. Guppy, J. M. Littleton

Research output: Contribution to journalArticlepeer-review

Abstract

Histamine inhibits IL-4 secretion from T helper type 2 cells but enhances IL-5 secretion from the same cells. Both of these effects are mediated by H2 receptors. Not all cyclic AMP-elevating agents affect IL-4 and IL-5 secretion. The observations suggest a selective effect of histamine on TH2 lymphocytes. Furthermore, Cl- channels may be involved in histamine-mediated regulation of cytokine secretion. The data suggest that histamine-induced elevation of cyclicAMP may be an important, but probably not the sole, mechanism underlying the selective effects of histamine on cytokine production.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalProceedings of the Western Pharmacology Society
Volume38
StatePublished - 1995

ASJC Scopus subject areas

  • Pharmacology

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