Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats

L. J. Guppy; J. M. Littleton

Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats

L. J. Guppy, J. M. Littleton

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Histamine inhibits IL-4 secretion from T helper type 2 cells but enhances IL-5 secretion from the same cells. Both of these effects are mediated by H₂ receptors. Not all cyclic AMP-elevating agents affect IL-4 and IL-5 secretion. The observations suggest a selective effect of histamine on TH₂ lymphocytes. Furthermore, Cl^- channels may be involved in histamine-mediated regulation of cytokine secretion. The data suggest that histamine-induced elevation of cyclicAMP may be an important, but probably not the sole, mechanism underlying the selective effects of histamine on cytokine production.

Original language	English
Pages (from-to)	73-75
Number of pages	3
Journal	Proceedings of the Western Pharmacology Society
Volume	38
State	Published - 1995

ASJC Scopus subject areas

Pharmacology

Cite this

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title = "Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats",

abstract = "Histamine inhibits IL-4 secretion from T helper type 2 cells but enhances IL-5 secretion from the same cells. Both of these effects are mediated by H2 receptors. Not all cyclic AMP-elevating agents affect IL-4 and IL-5 secretion. The observations suggest a selective effect of histamine on TH2 lymphocytes. Furthermore, Cl- channels may be involved in histamine-mediated regulation of cytokine secretion. The data suggest that histamine-induced elevation of cyclicAMP may be an important, but probably not the sole, mechanism underlying the selective effects of histamine on cytokine production.",

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year = "1995",

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AU - Guppy, L. J.

AU - Littleton, J. M.

PY - 1995

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N2 - Histamine inhibits IL-4 secretion from T helper type 2 cells but enhances IL-5 secretion from the same cells. Both of these effects are mediated by H2 receptors. Not all cyclic AMP-elevating agents affect IL-4 and IL-5 secretion. The observations suggest a selective effect of histamine on TH2 lymphocytes. Furthermore, Cl- channels may be involved in histamine-mediated regulation of cytokine secretion. The data suggest that histamine-induced elevation of cyclicAMP may be an important, but probably not the sole, mechanism underlying the selective effects of histamine on cytokine production.

AB - Histamine inhibits IL-4 secretion from T helper type 2 cells but enhances IL-5 secretion from the same cells. Both of these effects are mediated by H2 receptors. Not all cyclic AMP-elevating agents affect IL-4 and IL-5 secretion. The observations suggest a selective effect of histamine on TH2 lymphocytes. Furthermore, Cl- channels may be involved in histamine-mediated regulation of cytokine secretion. The data suggest that histamine-induced elevation of cyclicAMP may be an important, but probably not the sole, mechanism underlying the selective effects of histamine on cytokine production.

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JO - Proceedings of the Western Pharmacology Society

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ER -

Partial left ventricular ischemia in isolated hearts obtained from ethanol-dependent rats

Abstract

ASJC Scopus subject areas

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