A new procedure for assembling the cholestane side chain from 20-oxopregnanes involved the sequential construction of the C-20,22 and C-24,25 bonds via the sequential α,γ-dialkylation of 1-(phenylthio)-1-(trimethylsilyl)-2-propene. A stereoselective, partial synthesis of (20R,22R)-20,22-dihydroxycholesterol served to test the validity of this approach.
|Number of pages||7|
|Journal||Journal of Organic Chemistry|
|State||Published - Dec 1981|
ASJC Scopus subject areas
- Organic Chemistry