TY - GEN
T1 - Partial volume effect of cingulum tract in diffusion-tensor MRI
AU - Cao, Ning
AU - Gold, Brian T.
AU - Zhang, Jun
PY - 2008
Y1 - 2008
N2 - Diffusion tensor imaging (DTI) represents a promising tool for the early diagnosis of certain brain diseases. Many DTI studies have compared differences in local diffusivity in specific region-of- interest (ROI) between patient and control groups to find possible disease markers. However, local diffusivity results may be influenced by partial volume effects (PVE), particularly in small white matter tracts that border grey matter tissue. Here, we investigated the influence of PVE on local diffusivity measurements in a small but critical white matter tract, the cingulum. Results demonstrated significant variability in PVE that contribute to local diffusivity in the cingulum. Our results highlight the need for careful consideration of PVE when computing diffusivity of small tissues.
AB - Diffusion tensor imaging (DTI) represents a promising tool for the early diagnosis of certain brain diseases. Many DTI studies have compared differences in local diffusivity in specific region-of- interest (ROI) between patient and control groups to find possible disease markers. However, local diffusivity results may be influenced by partial volume effects (PVE), particularly in small white matter tracts that border grey matter tissue. Here, we investigated the influence of PVE on local diffusivity measurements in a small but critical white matter tract, the cingulum. Results demonstrated significant variability in PVE that contribute to local diffusivity in the cingulum. Our results highlight the need for careful consideration of PVE when computing diffusivity of small tissues.
KW - Diffusion tensor imaging
KW - Partial volume effect
UR - http://www.scopus.com/inward/record.url?scp=44349143787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44349143787&partnerID=8YFLogxK
U2 - 10.1117/12.770962
DO - 10.1117/12.770962
M3 - Conference contribution
AN - SCOPUS:44349143787
SN - 9780819471000
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images
T2 - Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images
Y2 - 17 February 2008 through 19 February 2008
ER -