Pathogenesis of bronchopulmonary dysplasia

Don Hayes, David J. Feola, Brian S. Murphy, Lori A. Shook, Hubert O. Ballard

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Bronchopulmonary dysplasia (BPD) refers to a heterogeneous group of lung disorders in infants that is commonly associated with prematurity and surfactant deficiency. BPD results from the complex interplay between impairments in the premature lung such as surfactant deficiency, perinatal insults such as infection, and damage resulting from supportive care of the infant due to barotrauma or volutrauma from mechanical ventilation and oxygen toxicity from supplemental oxygen administration. These factors result in chronic inflammation in the infant lung with recurring cycles of lung damage and repair that may impair alveolarization and vascularization in the developing lungs. As our insight in how to treat BPD improves along with the ability to do so with developing technology and therapies, the underlying pathogenesis will also change. The term 'new' BPD is now commonly used, to describe the changes seen in the post-surfactant era. This discussion reviews the pathogenesis of BPD according to the current medical literature.

Original languageEnglish
Pages (from-to)425-436
Number of pages12
JournalRespiration
Volume79
Issue number5
DOIs
StatePublished - Apr 2010

Keywords

  • Bronchopulmonary dysplasia
  • Chronic lung disease of infancy
  • Pathogenesis
  • Pathophysiology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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