TY - JOUR
T1 - Pathophysiology of heart failure update
T2 - the role of neurohumoral activation in the progression of heart failure.
AU - Moser, D. K.
PY - 1998/5
Y1 - 1998/5
N2 - Understanding the pathophysiologic mechanisms responsible for producing heart failure is necessary before effective treatments can be developed that increase survival and improve quality of life. Recent advances in the treatment of heart failure can be traced directly to improved appreciation of the role of neurohumoral activation in the pathophysiology of heart failure. Initially adaptive, neurohumoral activation ultimately results in a series of overadjustments that actively participate in the progression of heart failure. In this article, the role of neurohumoral activation, ventricular remodeling, and various peripheral vascular abnormalities in the pathophysiology of heart failure are explored.
AB - Understanding the pathophysiologic mechanisms responsible for producing heart failure is necessary before effective treatments can be developed that increase survival and improve quality of life. Recent advances in the treatment of heart failure can be traced directly to improved appreciation of the role of neurohumoral activation in the pathophysiology of heart failure. Initially adaptive, neurohumoral activation ultimately results in a series of overadjustments that actively participate in the progression of heart failure. In this article, the role of neurohumoral activation, ventricular remodeling, and various peripheral vascular abnormalities in the pathophysiology of heart failure are explored.
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U2 - 10.1097/00044067-199805000-00002
DO - 10.1097/00044067-199805000-00002
M3 - Review article
C2 - 9633270
AN - SCOPUS:0032059268
SN - 1079-0713
VL - 9
SP - 157
EP - 171
JO - AACN clinical issues
JF - AACN clinical issues
IS - 2
ER -