Pathophysiology of spinal cord trauma

Douglas K. Anderson, Edward D. Hall

Research output: Contribution to journalReview articlepeer-review

237 Scopus citations

Abstract

This article reviews the pathophysiology of spinal cord injury. The focus is on the role of post-traumatic membrane lipid changes, including lipid hydrolysis with enzymatic lipid peroxidation (ie, eicosanoid production) and nonenzymatic, free radical-induced lipid peroxidation in the secondary autodestruction of injured spinal cord tissue. A speculative etiopathogenesis of secondary injury is presented in an attempt to explain the importance and order of the pathophysiologic events that result in tissue death and the apparent effectiveness of diverse pharmacologic agents in the treatment of experimental spinal cord injury.

Original languageEnglish
Pages (from-to)987-992
Number of pages6
JournalAnnals of Emergency Medicine
Volume22
Issue number6
DOIs
StatePublished - Jun 1993

Bibliographical note

Funding Information:
Original studies from the authors' laboratories reviewed in this article were funded by the Department of Veterans Affairs, Upjohn Company, American Paralysis Association, and Spinal Cord Research Foundation of the Paralyzed Veterans of America.

Keywords

  • spinal cord
  • trauma

ASJC Scopus subject areas

  • Emergency Medicine

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