Abstract
This article reviews the pathophysiology of spinal cord injury. The focus is on the role of post-traumatic membrane lipid changes, including lipid hydrolysis with enzymatic lipid peroxidation (ie, eicosanoid production) and nonenzymatic, free radical-induced lipid peroxidation in the secondary autodestruction of injured spinal cord tissue. A speculative etiopathogenesis of secondary injury is presented in an attempt to explain the importance and order of the pathophysiologic events that result in tissue death and the apparent effectiveness of diverse pharmacologic agents in the treatment of experimental spinal cord injury.
Original language | English |
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Pages (from-to) | 987-992 |
Number of pages | 6 |
Journal | Annals of Emergency Medicine |
Volume | 22 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1993 |
Bibliographical note
Funding Information:Original studies from the authors' laboratories reviewed in this article were funded by the Department of Veterans Affairs, Upjohn Company, American Paralysis Association, and Spinal Cord Research Foundation of the Paralyzed Veterans of America.
Funding
Original studies from the authors' laboratories reviewed in this article were funded by the Department of Veterans Affairs, Upjohn Company, American Paralysis Association, and Spinal Cord Research Foundation of the Paralyzed Veterans of America.
Funders | Funder number |
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American Paralysis Association | |
Upjohn Company | |
U.S. Department of Veterans Affairs |
Keywords
- spinal cord
- trauma
ASJC Scopus subject areas
- Emergency Medicine