Pattern of grade C molar-incisor pattern periodontitis in families

Mostafa Tabaa, Reuben Adatowovor, Avesta Shabila, Lorri Morford, Dolph Dawson, Peter Harrison, Ikramuddin Aukhil, Hong Huang, Arnold Stromberg, Jussara Goncalves, Luciana M. Shaddox

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to determine the clinical and inflammatory response patterns for individual siblings diagnosed with grade C molar-incisor pattern periodontitis (C-MIP) and between the related siblings within families. Methods: Sixty-nine siblings within 28 families with moderate-to-severe C-MIP were included. Clinical parameters were evaluated for symmetry regarding the affected type of teeth, side and/or arch, and bone loss pattern. The protein concentrations from in vitro whole blood cultures for 14 different lipopolysaccharide-stimulated inflammatory markers were correlated with the extent and severity of disease, within an individual sibling and among siblings within a family. Results: A similar disease pattern was observed among all siblings and within families. The most common teeth affected were first molars and incisors or first molars only within the permanent dentition and only molars within the primary dentition (p < 0.001). Symmetry involving molars was higher than in incisors in siblings, regardless of arch or side affected (p = 0.020). Arc-shape/vertical bone defects were the most common (p = 0.006) and higher symmetry was found for these defects in the permanent dentition (p = 0.005). Positive correlations were found between age, clinical attachment loss, and percent affected sites with several inflammatory markers. The inflammatory responses for several inflammatory markers were correlated within and among families (p < 0.050). Specifically, the intraclass correlation coefficient within families was highest (>0.5) for interleukin (IL)-8, IL-6, and IL-10. Conclusions: Families with C-MIP presented similar patterns of disease. The level of an inflammatory response to bacteria seemed to play a role in the extent and severity of this disease, exemplified by the high degree of correlation in these families.

Original languageEnglish
Pages (from-to)811-822
Number of pages12
JournalJournal of Periodontology
Volume94
Issue number7
DOIs
StatePublished - Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 American Academy of Periodontology.

Keywords

  • biomarker
  • clinical study
  • cytokines
  • host response
  • inflammation
  • periodontal disease
  • symmetry

ASJC Scopus subject areas

  • Periodontics

Fingerprint

Dive into the research topics of 'Pattern of grade C molar-incisor pattern periodontitis in families'. Together they form a unique fingerprint.

Cite this