Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of aged, memory deficient rats

P. W. Landfield, G. Rose, L. Sandles, T. C. Wohlstadter, G. Lynch

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

The brains of aged and young Fischer rats were examined using a modified version of Cajal's gold chloride stain for astrocytes. A sizable loss of pyramidal cells and remarkably hypertrophic astrocytes were found in the hippocampus of the aged animals, while the astrocytic changes were not seen in other forebrain regions. Four major characteristics of the pattern of hippocampal astrogliosis were noted: the astrocytes were often found to be grouped in clusters; grouped astrocytes were commonly seen to have similarly oriented processes; small blood vessels were more often stained in regions of pyramidal cell degeneration and astroglial hypertrophy; and reactive astrocytes were in several instances found to be gathered on the 'border' between deteriorated regions and healthier appearing areas. This pattern was interpreted to suggest that the astrocyte clusters may be analogous to senile plaques. Since the aged Fischer animals have previously been found to exhibit retention deficits, the possibility that the hippocampal pathology is related to impaired memory in these animals was raised.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalUnknown Journal
Volume32
Issue number1
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Aging

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