PDCD4

Hsin Sheng Yang; Qing Wang; Magdalena M. Bajer; Tobias Schmid

doi:10.1007/978-94-017-9078-9_6

PDCD4

Hsin Sheng Yang, Qing Wang, Magdalena M. Bajer, Tobias Schmid

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

Original language	English
Title of host publication	Translation and Its Regulation in Cancer Biology and Medicine
Pages	135-161
Number of pages	27
ISBN (Electronic)	9789401790789
DOIs	https://doi.org/10.1007/978-94-017-9078-9_6
State	Published - Mar 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Springer Science+Business Media Dordrecht. All rights reserved.

Keywords

Cancer
Cell signaling
PDCD4
RNA helicase
S6 kinase (S6K)
Translation initiation
Tumor suppressor
eIF4A
mTOR pathway
miR-21

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-94-017-9078-9_6

Cite this

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T1 - PDCD4

AU - Yang, Hsin Sheng

AU - Wang, Qing

AU - Bajer, Magdalena M.

AU - Schmid, Tobias

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N2 - PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

AB - PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

KW - Cancer

KW - Cell signaling

KW - PDCD4

KW - RNA helicase

KW - S6 kinase (S6K)

KW - Translation initiation

KW - Tumor suppressor

KW - eIF4A

KW - mTOR pathway

KW - miR-21

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DO - 10.1007/978-94-017-9078-9_6

M3 - Chapter

AN - SCOPUS:84930902508

SN - 9401790779

SN - 9789401790772

SP - 135

EP - 161

BT - Translation and Its Regulation in Cancer Biology and Medicine

ER -

PDCD4

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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