Hsin Sheng Yang, Qing Wang, Magdalena M. Bajer, Tobias Schmid

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


PDCD4 is a novel tumor suppressor. Its expression is frequently downregulated in many types of cancers, and it has been demonstrated to inhibit tumor promotion and progression. The biochemical function of PDCD4 is the inhibition of translation through binding to eIF4A helicase. In this review, we will focus on recent advances in understanding the mechanism of inhibiting translation and tumorigenesis by PDCD4, the regulation of PDCD4 expression and the potential application of PDCD4 as a target for cancer diagnostics and therapeutics.

Original languageEnglish
Title of host publicationTranslation and Its Regulation in Cancer Biology and Medicine
Number of pages27
ISBN (Electronic)9789401790789
StatePublished - Mar 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Springer Science+Business Media Dordrecht. All rights reserved.


  • Cancer
  • Cell signaling
  • PDCD4
  • RNA helicase
  • S6 kinase (S6K)
  • Translation initiation
  • Tumor suppressor
  • eIF4A
  • mTOR pathway
  • miR-21

ASJC Scopus subject areas

  • General Medicine


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