PEGylation of nanocarrier drug delivery systems: State of the art

Melissa D. Howard, Michael Jay, Thomas D. Dziubla, Xiuling Lu

Research output: Contribution to journalReview articlepeer-review

171 Scopus citations

Abstract

"PEGylation" has become the most widely used method for imparting stealth properties to drug nanocarriers. PEGylation of nanoparticles provides a steric barrier to the adsorption of opsonin proteins due to the neutrality, hydrophilicity, flexibility, and capacity for hydration of the PEG moiety. PEGylation of particle surfaces can be achieved by simple adsorption or through the covalent attachment of PEG to activated functional groups on the surface of the particles. PEG molecules have also been modified to enhance their uptake by specific targets (e.g., tumors) and to achieve the controlled release of entrapped therapeutic agents. Accompanying the prevalence of PEGylation has been the development of a wide variety of characterization techniques and the increasing use of mathematical modeling to guide formulation development. This review summarizes the theories behind PEGylation, PEGylation methodology, the characterization of PEGylated particles, and related mathematical modeling as well as how it can be utilized in the optimization of nanocarrier drug delivery systems. The current successes and failures of PEGylation are evaluated in order to provide a vision for the future of nanocarrier PEGylation and nanomedicine in general.

Original languageEnglish
Pages (from-to)133-148
Number of pages16
JournalJournal of Biomedical Nanotechnology
Volume4
Issue number2
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'PEGylation of nanocarrier drug delivery systems: State of the art'. Together they form a unique fingerprint.

Cite this