Perinatal diet influences health and survival in a mouse model of leukemia

Dushani L. Palliyaguru, Annamaria L. Rudderow, Alex M. Sossong, Kaitlyn N. Lewis, Caitlin Younts, Kevin J. Pearson, Michel Bernier, Rafael de Cabo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.

Original languageEnglish
Pages (from-to)1147-1155
Number of pages9
Issue number4
StatePublished - Aug 1 2020

Bibliographical note

Publisher Copyright:
© 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.


  • Adiposity
  • Lifespan
  • Maternal gestational diets
  • Perinatal interventions
  • Post-natal environment

ASJC Scopus subject areas

  • Aging
  • Veterinary (miscellaneous)
  • Complementary and alternative medicine
  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine


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