Perinatal diet influences health and survival in a mouse model of leukemia

Dushani L. Palliyaguru; Annamaria L. Rudderow; Alex M. Sossong; Kaitlyn N. Lewis; Caitlin Younts; Kevin J. Pearson; Michel Bernier; Rafael de Cabo

doi:10.1007/s11357-020-00199-9

Perinatal diet influences health and survival in a mouse model of leukemia

Dushani L. Palliyaguru, Annamaria L. Rudderow, Alex M. Sossong, Kaitlyn N. Lewis, Caitlin Younts, Kevin J. Pearson, Michel Bernier, Rafael de Cabo

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.

Original language	English
Pages (from-to)	1147-1155
Number of pages	9
Journal	GeroScience
Volume	42
Issue number	4
DOIs	https://doi.org/10.1007/s11357-020-00199-9
State	Published - Aug 1 2020

Bibliographical note

Publisher Copyright:
© 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Funding

This work was supported by funding from the Intramural Research Program of the National Institute on Aging/NIH. Acknowledgements

Funders	Funder number
National Institutes of Health (NIH)
National Institute on Aging	ZIAAG000363

Keywords

Adiposity
Lifespan
Maternal gestational diets
Perinatal interventions
Post-natal environment

ASJC Scopus subject areas

Aging
Veterinary (miscellaneous)
Complementary and alternative medicine
Geriatrics and Gerontology
Cardiology and Cardiovascular Medicine

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10.1007/s11357-020-00199-9

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title = "Perinatal diet influences health and survival in a mouse model of leukemia",

abstract = "The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.",

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author = "Palliyaguru, \{Dushani L.\} and Rudderow, \{Annamaria L.\} and Sossong, \{Alex M.\} and Lewis, \{Kaitlyn N.\} and Caitlin Younts and Pearson, \{Kevin J.\} and Michel Bernier and \{de Cabo\}, Rafael",

note = "Publisher Copyright: {\textcopyright} 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

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doi = "10.1007/s11357-020-00199-9",

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AU - Palliyaguru, Dushani L.

AU - Rudderow, Annamaria L.

AU - Sossong, Alex M.

AU - Lewis, Kaitlyn N.

AU - Younts, Caitlin

AU - Pearson, Kevin J.

AU - Bernier, Michel

AU - de Cabo, Rafael

PY - 2020/8/1

Y1 - 2020/8/1

N2 - The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.

AB - The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.

KW - Adiposity

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KW - Maternal gestational diets

KW - Perinatal interventions

KW - Post-natal environment

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Perinatal diet influences health and survival in a mouse model of leukemia

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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