Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s)

Julie S. Pendergast, Gisele A. Oda, Kevin D. Niswender, Shin Yamazaki

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Daily rhythmic processes are coordinated by circadian clocks, which are present in numerous central and peripheral tissues. In mammals, two circadian clocks, the food-entrainable oscillator (FEO) and methamphetamine-sensitive circadian oscillator (MASCO), are "black box" mysteries because their anatomical loci are unknown and their outputs are not expressed under normal physiological conditions. In the current study, the investigation of the time keeping mechanisms of the FEO and MASCO in mice with disruption of all three paralogs of the canonical clock gene, Period, revealed unique and convergent findings. We found that both the MASCO and FEO in Per1-/-/Per2-/-/Per3-/- mice are circadian oscillators with unusually short (∼21 h) periods. These data demonstrate that the canonical Period genes are involved in period determination in the FEO and MASCO, and computational modeling supports the hypothesis that the FEO and MASCO use the same timekeeping mechanism or are the same circadian oscillator. Finally, these studies identify Per1-/-/Per2-/-/Per3-/- mice as a unique tool critical to the search for the elusive anatomical location(s) of the FEO and MASCO.

Original languageEnglish
Pages (from-to)14218-14223
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number35
StatePublished - Aug 28 2012


  • C57BL/6J
  • Food anticipatory activity
  • Knockout
  • Restricted feeding
  • Suprachiasmatic nuclei

ASJC Scopus subject areas

  • General


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