Periodontal health and disease: The contribution of genetics

Luciana Macchion Shaddox; Lorri Ann Morford; Luigi Nibali

doi:10.1111/prd.12357

Periodontal health and disease: The contribution of genetics

Luciana Macchion Shaddox, Lorri Ann Morford, Luigi Nibali

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.

Original language	English
Pages (from-to)	161-181
Number of pages	21
Journal	Periodontology 2000
Volume	85
Issue number	1
DOIs	https://doi.org/10.1111/prd.12357
State	Published - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Keywords

epigenetics
genetic variation
microbiology
periodontitis/periodontal disease
single nucleotide polymorphism

ASJC Scopus subject areas

Periodontics

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10.1111/prd.12357

Cite this

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abstract = "Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.",

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AB - Periodontitis is an infectious, inflammatory disease that is associated with a complex interplay between specific bacteria, host response, and environmental factors. Because of its high degree of familial aggregation, specifically for the more aggressive forms of the disease, genetics factors have been implicated in disease pathogenesis for several decades. This review provides an overview of what we currently know regarding the genetic and epigenetic contributions to periodontal disease and discusses future opportunities in the field.

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KW - microbiology

KW - periodontitis/periodontal disease

KW - single nucleotide polymorphism

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Periodontal health and disease: The contribution of genetics

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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